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The success of the Nigeria programme hinges on the active participation of everyone to make sure that all children are reached by National Immunization Days (NIDs), Immunization Plus Days (IPDs) and the routine immunization programme, if the country capitalizes on the commitments I've heard in the past two days, Nigeria can lead the way to a polio-free Africa.

— Bill Gates Regarding Bill And Melinda Gates' Polio Efforts (2009)

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The obvious mathematical breakthrough would be development of an easy way to factor large prime numbers.

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Quote text and notes from Wikiquote: Bill Gates (page history), available under CC BY-SA 4.0. Source quality and labels are our own summary of what Wikiquote records.