Great things are not accomplished by those who yield to trends and fads and popular opinion.
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This is not a quote by Kerouac. It's a quote by CBS broadcaster Charles Kuralt who used to present a TV news segment called 'On the Road' (which is probably how the confusion arose). This particular statement by Kuralt was made in May 1996 to students of Skidmore College, Saratoga Springs, New York: news.google.com