The purpose of separation of church and state is to keep forever from these shores the ceaseless strife that has soaked the soil of Europe in blood for centuries.

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Source, in full

Though this had been cited as being from a letter objecting to the use of government land for churches in 1803, as quoted in 2000 Years of Disbelief: Famous People With the Courage to Doubt (1996) edited by James A Haught, no original source for this has yet been found.

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Attribution

Quote text and notes from Wikiquote: James Madison (page history), available under CC BY-SA 4.0. Source quality and labels are our own summary of what Wikiquote records.