Youth ages, immaturity is outgrown, ignorance can be educated, drunkenness sobered, but stupid lasts forever.
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Source, in full
Fictional attribution in the movie The Emperor's Club (2002), given by Kevin Kline (as William Hundert); also attributed to Diogenes, without sources; no published occurrences of this statement prior to the movie have been located in any of the Aristophanes Plays or Fragments.