Prayer offered up at night possesses a great power, more than the prayer of the day-time. Therefore all the righteous prayed during the night, while combatting the heaviness of the body and the sweetness of sleep and repelling corporeal nature.

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Notes from Wikiquote

And again, ‘At midnight I arose to give thanks unto Thee for the judgments of Thy righteousness.’ | And for every entreaty for which they urgently besought God, they armed themselves with the prayer of night vigil, and at once they received their request. | Homily 75, p. 523

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Quote text and notes from Wikiquote: Isaac of Nineveh (page history), available under CC BY-SA 4.0. Source quality and labels are our own summary of what Wikiquote records.