Anything done for the first time unleashes a demon. (Cover and title of Cerebus #65, August 1984, collected in Church & State I, p. 7 and 273)

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Source, in full

Usually quoted with "Anything" unspaced (as in the title p. 7), sometimes quoted spaced (as in the art p. 273, as "Any thing done for the first time unleashes a demon.") because the cover art piles "Any" and "thing" (though they are joined, the leg of the "y" being also the bar of the "t").

Notes from Wikiquote

Compare to a quote misattributed to Emily Dickinson: "Whenever a thing is done for the first time, it releases a little demon." (origin and date unknown, also attributed to Dave Sim)

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Attribution

Quote text and notes from Wikiquote: Dave Sim (page history), available under CC BY-SA 4.0. Source quality and labels are our own summary of what Wikiquote records.