Anything done for the first time unleashes a demon. (Cover and title of Cerebus #65, August 1984, collected in Church & State I, p. 7 and 273)
Source, in full
Usually quoted with "Anything" unspaced (as in the title p. 7), sometimes quoted spaced (as in the art p. 273, as "Any thing done for the first time unleashes a demon.") because the cover art piles "Any" and "thing" (though they are joined, the leg of the "y" being also the bar of the "t").
Notes from Wikiquote
Compare to a quote misattributed to Emily Dickinson: "Whenever a thing is done for the first time, it releases a little demon." (origin and date unknown, also attributed to Dave Sim)