I feel that there is something in having passed one's childhood beside the big river, which is incommunicable to those people who have not.

Letter to Marquis Childs quoted in St. Louis Post Dispatch (15 October 1930) and in the address "American Literature and the American Language" delivered at Washington University (9 June 1953) published in Washington University Studies, New Series: Literature and Language, no. 23 (St. Louis : Washington University Press, 1953), p. 6