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born 1955 Ivory Coast
Pascale Guiton is a microbiologist and assistant professor at Santa Clara University, where she focuses on both teaching and research. She specializes in parasitology, particularly the study of Toxoplasma gondii.
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How proteins are trafficked to these organelles is not known, and is something we also hope to uncover.
The main question of my research program is ‘how does Toxoplasma initiate infection in a new host.
In a way the techniques we use are a bit more basic and the students need to learn how to perform them.
Infectious diseases are one of those things that we live with, and growing up, you had to get vaccinated.
The hardest part was doing all the things behind the scenes that you don't know about, all the paperwork.
With bradyzoites, we can look at them in vitro and in mice and they can be easily deactivated.
There are obviously risks with this approach, and the progress can be slow well it is slow.
It's one of those things that is all around you, even if you don't really think about it.
What they demonstrated to us is that they will continue to operate, whether individual faculty are there or not.
It’s up to faculty to stand up and say, ‘There is no university without the faculty.’
I am also looking at the transcriptional regulation in the parasite and how this affects its metabolism and virulence.
Microbiology is also at the intersection of so many different scientific fields.
If the university would hire lecturers to provide relief from teaching loads.
I'm interested in looking at the interaction of Toxoplasma with goblet cells.
Part of that is asking ‘what are the molecular mechanisms that the parasite uses to interact with the gastrointestinal tract.
They are lifelong proficiencies applicable to other aspects of their lives.
Doing the herbarium and having to separate the petals of the flower, the sepal, knowing the names of the different structures.
I strongly believe that with the active participation of both individuals.
During this lifecycle, Toxoplasma also undergoes transcriptional changes.
I am focusing on bradyzoites because sporozoites are highly infectious.
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